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Wiley, Angewandte Chemie International Edition, 31(51), p. 7812-7816, 2012

DOI: 10.1002/anie.201202945

Wiley, Angewandte Chemie, 31(124), p. 7932-7936, 2012

DOI: 10.1002/ange.201202945

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Probing bacterial-toxin inhibition with synthetic glycopolymers prepared by tandem post-polymerization modification : role of linker length and carbohydrate density

Journal article published in 2012 by Sarah-Jane 1988 Richards ORCID, Mathew W. Jones, Mark Hunaban, David M. Haddleton ORCID, Matthew I. Gibson ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Probing the depths: A tandem post-polymerization modification strategy was used to systematically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see scheme), carbohydrate density, and glycopolymer chain length. Guided by structural-biology information, the binding-pocket depth of the toxin was probed and used as a means to specifically improve inhibition of the toxin by the glycopolymer.