Wiley, Angewandte Chemie International Edition, 31(51), p. 7812-7816, 2012
Wiley, Angewandte Chemie, 31(124), p. 7932-7936, 2012
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Probing the depths: A tandem post-polymerization modification strategy was used to systematically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see scheme), carbohydrate density, and glycopolymer chain length. Guided by structural-biology information, the binding-pocket depth of the toxin was probed and used as a means to specifically improve inhibition of the toxin by the glycopolymer.