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American Society for Microbiology, mBio, 3(3), 2012

DOI: 10.1128/mbio.00118-12

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Escherichia coli: Great Diversity around a Common Core

Journal article published in 2012 by Danilo G. Moriel, Roberto Rosini, Kate L. Seib ORCID, Laura Serino, Mariagrazia Pizza, Rino Rappuoli
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The 2011 Escherichia coli outbreak in Germany, which resulted in more than 4,000 cases, including 908 cases of hemolytic-uremic syndrome (HUS) and at least 50 deaths, highlighted the genome plasticity of E. coli and the potential for new virulent strains to emerge. The analysis of 170 E. coli genome sequences for the presence of nine previously identified protective extraintestinal pathogenic E. coli antigens suggested the feasibility of a combination vaccine as a universal intervention against all pathogenic E. coli strains. IMPORTANCE This article reports on the feasibility of a combination vaccine as a universal intervention against all pathogenic Escherichia coli strains.