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Wiley, Angewandte Chemie International Edition, 9(52), p. 2606-2610, 2013

DOI: 10.1002/anie.201209651

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Access to Organometallic Arylcobaltcorrins through Radical Synthesis: 4-Ethylphenylcobalamin, a Potential “Antivitamin B 12 ”

Journal article published in 2013 by Markus Ruetz, Carmen Gherasim, Karl Gruber ORCID, Sergey Fedosov, Ruma Banerjee, Bernhard Kräutler
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This paper is available in a repository.

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Abstract

Locked B(12) : 4-Ethylphenylcobalamin, a novel organometallic arylcobalamin, has been synthesized in a radical reaction. This vitamin B(12) antimetabolite features a strong CoC bond, and represents a "locked" form of vitamin B(12) . It may be used in animal studies to induce functional vitamin B(12) deficiency artificially to help clarify still controversial issues related to the pathophysiology of vitamin B(12) deficiency.