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Wiley, FEBS Letters, 9(587), p. 1379-1384, 2013

DOI: 10.1016/j.febslet.2013.03.012

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Identification and characterization of the nano-sized vesicles released by muscle cells

Journal article published in 2013 by Daniele P. Romancino ORCID, Gaetano Paterniti, Yvan Campos, Angela De Luca, Valentina Di Felice ORCID, Alessandra d'Azzo, Antonella Bongiovanni
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Several cell types secrete small membranous vesicles that contain cell-specific collections of proteins, lipids, and genetic material. The function of these vesicles is to allow cell-to-cell signaling and the horizontal transfer of their cargo molecules. Here, we demonstrate that muscle cells secrete nano-sized vesicles and that their release increases during muscle differentiation. Analysis of these nanovesicles allowed us to characterize them as exosome-like particles and to define the potential role of the multifunctional protein Alix in their biogenesis.