2006 IEEE International Geoscience and Remote Sensing Symposium. IGARSS. Denver, CO, USA, 31 July - 4 August, 53 - 56 ; Content-based querying allows efficient retrieval of images based on the information they contain, rather than acquisition date or geographical extent. We extend the potential of a content-based image retrieval (CBIR) system based on Self- Organizing Maps (SOMs), to the analysis of remote sensing data. A database was artificially created by splitting each satellite image to be analyzed into small images. After training the CBIR system on this imagelet database, both interactive and off-line queries were made to detect man-made structures, as well as changes. Experimental results suggest that this new approach is suitable for analyzing very high-resolution optical satellite imagery. Possible applications include interactive detection of man-made structures and supervised monitoring of sensitive sites.