Published in
Cell Press, Chemistry and Biology, 2(20), p. 140-142, 2013
DOI: 10.1016/j.chembiol.2013.02.005
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In search of the missing ligands for TetR family regulators
Journal article published in 2013 by
Christophe Corre 
This paper is made freely available by the publisher.
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Abstract
The TetR family of microbial transcription factors directly control the expression of a diverse range of genes in bacteria by sensing specific ligands. In this issue of Chemistry & and Biology, Cuthbertson and colleagues used phylogenomics to guide the identification of TetR-like protein cognate ligands and revealed a novel inducible antibiotic resistance mechanism.