Elsevier, Tetrahedron, 23(71), p. 3795-3801, 2015
DOI: 10.1016/j.tet.2015.03.094
Full text: Unavailable
通讯作者地址: Huang, PQ ; Triflic anhydride in combination with 2-fluoropyridine effectively dehydrates secondary amides to afford nitriles under mild reaction conditions. The reaction is general in scope and compatible with the use of aliphatic, alpha,beta-unsaturated, aromatic, and heteroaromatic amides bearing either secondary, tertiary, or benzylic N-alkyl groups. The reaction also shows good to excellent chemoselectivity for the secondary amide and tolerates several labile functional groups. ; Natural Science Foundation of China (NSFC) 21332007 Program for Changjiang Scholars and Innovative Research Team in University of the Ministry of Education of China