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Elsevier, Tetrahedron, 23(71), p. 3795-3801, 2015

DOI: 10.1016/j.tet.2015.03.094

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Versatile and chemoselective transformation of aliphatic and aromatic secondary amides to nitriles

Journal article published in 2015 by Hui Geng, 黄培强, Pei-Qiang Huang ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

通讯作者地址: Huang, PQ ; Triflic anhydride in combination with 2-fluoropyridine effectively dehydrates secondary amides to afford nitriles under mild reaction conditions. The reaction is general in scope and compatible with the use of aliphatic, alpha,beta-unsaturated, aromatic, and heteroaromatic amides bearing either secondary, tertiary, or benzylic N-alkyl groups. The reaction also shows good to excellent chemoselectivity for the secondary amide and tolerates several labile functional groups. ; Natural Science Foundation of China (NSFC) 21332007 Program for Changjiang Scholars and Innovative Research Team in University of the Ministry of Education of China