A goal of the Biomedical Informatics Research Network (BIRN) project sponsored by NCRR/NIH is to develop a multi- institution information management system for Neurosciences, where each participating institution produces a database of their experimen- tal or computationally derived data, and a mediator module performs semantic integration over the databases to enable neuroscientists to per- form analyses that could not be executed from any single institution's data. This demonstration paper briefly describes the current capabilities of Metropolis-II, the information integration system for BIRN.