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Wiley, Histopathology, 7(54), p. 837-846, 2009

DOI: 10.1111/j.1365-2559.2009.03311.x

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Expression of the interferon-inducible proteins MxA and IFI16 in liver allografts

Journal article published in 2009 by Cinzia Borgogna, Pierluigi Toniutto ORCID, Carlo Smirne, Barbara Azzimonti, Massimo Rittà, Claudio Avellini, Carlo Fabris, Santo Landolfo, Marisa Gariglio, Mario Pirisi
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

AIMS: To test the hypothesis that the activation of the interferon (IFN) system pathways might link hepatitis C virus (HCV) recurrence in the liver allograft with acute cellular rejection. METHODS AND RESULTS: In this retrospective study, allograft biopsy specimens from 28 adult patients (14 HCV+ and 14 HCV-) who had undergone their first liver transplantation were analysed. Eleven biopsy specimens showed acute cellular rejection (Banff rejection activity index score > or =3). Specimens were immunostained for two IFN-inducible proteins, MxA and IFI16, and for CD45. The predominant MxA reactivity pattern was hepatocytic, whereas IFI16 was expressed in both the hepatocellular and inflammatory compartments. Moderate to strong MxA expression in hepatocytes was associated positively with rejection score (P 40 U/l on the day of biopsy (P