Published in
American Chemical Society, Organic Letters, 21(15), p. 5468-5471
DOI: 10.1021/ol402617a
Links
Tools
Nicholas Reactions in the Synthesis of Dicobalt Dibenzocyclooctyne Complexes
Journal article published in 2013 by
Sinisa Djurdjevic,
James R. Green 
This paper is available in a repository.
Full text: Download
Preprint: archiving allowed
- Must obtain written permission from Editor
- Must not violate ACS ethical Guidelines
Postprint:
archiving restricted
- Must obtain written permission from Editor
- Must not violate ACS ethical Guidelines
Published version:
archiving forbidden
Data provided by 
Abstract
Hexacarbonyldicobalt complexes of biaryl-substituted 4-methoxybutynones and 4-methoxy-2-butynes undergo intramolecular Nicholas reactions to form dibenzocyclooctyne–Co2(CO)6 complexes in good yields. Reductive decomplexation of the cyclization products is possible, and the method has been applied to a formal synthesis of isoschizandrin.