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Elsevier, Immunity, 6(41), p. 873-875, 2014

DOI: 10.1016/j.immuni.2014.12.008

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A Swiss Army Knife for CTLs

Journal article published in 2014 by Peter Friedl, Bettina Weigelin ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Granzyme B released by leukocytes cleaves multiple intracellular substrates required for target cell lysis. In this issue of Immunity, Prakash etal. (2014) demonstrate that granzyme B cleaves basement membrane proteins and promotes cytotoxic Tcell diapedesis into inflamed tissue. Granzyme B released by leukocytes cleaves multiple intracellular substrates required for target cell lysis. Prakash etal. demonstrate that granzyme B cleaves basement membrane proteins and promotes cytotoxic Tcell diapedesis into inflamed tissue.