Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

Antony-Debré, Iléana; Manchev, Vladimir T.; Balayn, Nathalie; Bluteau, Dominique; Tomowiak, Cécile; Legrand, Céline; Langlois, Thierry; Bawa, Olivia; Tosca, Lucie; Tachdjian, Gérard; Leheup, Bruno; Debili, Najet; Plo, Isabelle; Mills, Jason A.; French, Deborah L.; Weiss, Mitchell J.; Solary, Eric; Favier, Remi; Vainchenker, William; Raslova, Hana

Published in

American Society of Hematology, Blood, 6(125), p. 930-940, 2015

DOI: 10.1182/blood-2014-06-585513

Tools

Export citation

Search in Google Scholar

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

Journal article published in 2015 by Iléana Antony-Debré, Vladimir T. Manchev, Nathalie Balayn, Dominique Bluteau, Cécile Tomowiak, Céline Legrand, Thierry Langlois, Olivia Bawa, Lucie Tosca, Gérard Tachdjian, Bruno Leheup, Najet Debili, Isabelle Plo, Jason A. Mills, Deborah L. French and other authors.

This paper is made freely available by the publisher.

Full text: Download

Preprint: archiving forbidden

Postprint: archiving restricted

Upload

Published version: archiving forbidden

Policy details

Data provided by

Abstract

Key Points A half loss of RUNX1 activity leads to defects in primitive erythropoiesis, megakaryopoiesis, and proplatelet formation. An almost complete loss of RUNX1 activity leads to the amplification of the granulomonocytic compartment with increased genomic instability.

Published in

Links

Tools

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

Abstract