Published in
Elsevier, Cancer Genetics and Cytogenetics, 1(29), p. 57-63
DOI: 10.1016/0165-4608(87)90030-6
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Duplication of Ph and of 9q+ chromosomes during the blastic transformation of a CML case.
Journal article published in 1987 by
Gian-Carlo Avanzi,
Avanzi Gc,
Bruna Giovinazzo,
Giuseppe Saglio,
Angelo Guerrasio 
,
Arturo Rosso,
Marilena Bertini,
Luigi Resegotti,
Luigi Pegoraro
,
Arturo Rosso,
Marilena Bertini,
Luigi Resegotti,
Luigi Pegoraro
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Abstract
We describe the blastic transformation of a case of chronic myelocytic leukemia in which, among other abnormalities, one extra Philadelphia and one extra 9q+ were observed. Molecular studies and analysis of the clonal evolution of the karyotype led to the interpretation of such an unusual finding as the result of nondisjunction, rather than of a double t(9;22) translocation.