Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia.
Journal article published in 2000 by
D. Capello,
U. Vitolo,
L. Pasqualucci,
S. Quattrone,
G. Migliaretti,
L. Fassone,
C. Ariatti,
D. Vivenza,
A. Gloghini,
C. Pastore,
C. Lanza,
J. Nomdedeu 
,
B. Botto,
R. Freilone,
D. Buonaiuto
and other authors.
,
B. Botto,
R. Freilone,
D. Buonaiuto
and other authors.
Abstract
BCL-6 mutations are accumulated during B-cell transit through the germinal center (GC) and provide a histogenetic marker for B-cell tumors. On the basis of a comprehensive analysis of 308 B-cell neoplasms, we (1) expand the spectrum of tumors associated with BCL-6 mutations; (2) corroborate the notion that mutations cluster with GC and post-GC B-cell neoplasms; and (3) identify heterogeneous mutation frequency among B-lineage diffuse large cell lymphoma (B-DLCL) subsets. Mutations are virtually absent in acute lymphoblastic leukemia (P