The information provided by the scientific studies and control measures implemented in the Pearl River Delta (PRD) region of China reveals that tremendous progress has been made in the understanding of regional air pollution issues and the deployment of mitigation measures for alleviating these problems. Given the unparalleled rapid economic growth in the PRD over the past two decades, such progress was only made possible by strong, science-based support and the partnerships between government and research institutions in the region and overseas. Researchers from these partnership programs and related studies have deployed cutting-edge expertise and experience in various crucial mainland China and mainland China/Hong Kong-level projects. China recognizes the importance of protecting the environment and cleaning up the air in the pursuit of sustainable growth and economic development. To avoid falling into a cycle of event-driven clean-up efforts, China has recently taken a major step and updated the national ambient air quality standards. Clearly, China is implementing an increasing number of evidence-based policies to address air pollution problems. Thus, to bring a fresh impetus at a national level, the PRD must maintain and augment the Hong Kong-mainland collaborative momentum, inducing a "whole-China" effort to clean up air pollution. To strengthen the science-based support system and ensure continuous and concerted effort in implementing the regional multi-pollutant control strategy, there must be an over-arching and integral Hong Kong-Guangdong science consortium framework supporting the formulation of regional policy and control measures built on common goals under the "one country, two systems" principle. The "PRD Approach" of the air quality management regime reflected regional cooperative efforts in synchronous air pollutant control, catalyzed the crucial role of information disclosure and subtly transformed the air quality management approach to overcome the nation's new air pollution challenges. (C) 2013 Elsevier Ltd. All rights reserved.