Many people believe that the plants are inherently safe and a useful tool for human health, because they are not considered “real drugs”. An increasing number of cases of poisoning has been registered dating back from the mid-90s up to now. In order to highlight the entity of plant exposures and to develop appropriate poisoning prevention and information, a retrospective analysis of the plant poisoning over a 12 year period (1995 – 2007) has been carried out. The Poison Control Center of Milan records over a thousand cases of plant poisoning peryear. One third of the cases involves children up to the age of 4 and the exposures originate mainly from accidental ingestion of houseplants or toxic plants around the house. In 15% of the cases adults were not able to give a description of the plant or to specify or describe the ingested part. More serious cases occur in adults whoeither erroneously confused a plant as edible or deliberately ingested a toxic plant. The incidence of plant poisoning depends on local customs, traditional recipes, nutritional factors, etc. It is important to identify the plants by their latin name, as common names vary from region to region and often the same common name is used to identify different plants.