Published in
Lippincott, Williams & Wilkins, AIDS, 11(18), p. 1598-1600, 2004
DOI: 10.1097/01.aids.0000131363.82951.fb
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A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children
Journal article published in 2004 by
Laura Braida,
Michele Boniotto 
,
Alessandra Pontillo ,
Pier Angelo Tovo,
Tovo Pa,
Antonio Amoroso ,
Sergio Crovella
,
Alessandra Pontillo ,
Pier Angelo Tovo,
Tovo Pa,
Antonio Amoroso ,
Sergio Crovella
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Abstract
In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.