<b><i>Introduction:</i></b> To investigate the accuracy of uroflowmetry with disposable Q_Single compared to measurements with a home-based digital device and compared to a single clinical measurement. <b><i>Patients and Methods:</i></b> 60 men with lower urinary tract symptoms were included in a prospective, open-label, multicenter study. Uroflowmetry measurements were done using three devices/methods: single clinic-based method, followed by up to 12 measurements using the disposable home-based Q_Single and up to 12 measurements using a home-based digital device. Subjective data on ease of use of Q_Single and preference of patients was investigated and objective measures of Q_max and voided volume from the three devices were compared. <b><i>Results:</i></b> Mean Q_max values of 12, 13 and 16 ml/s were achieved with the Q_Single device, standard clinic method, and digital device, respectively. Mean Q_max obtained with the Q_Single device did not differ from that obtained with the clinic method. A significantly higher mean Q_max was recorded for the digital device. Mean voided volumes recorded with each device differed marginally. Handling capabilities of the Q_Single device were considered good by all subjects. <b><i>Conclusions:</i></b> The accuracy of Q_max and voided volume mean measurements with Q_Single was comparable to one standard clinic recording. Q_Single offers a viable alternative to reduce the number of clinic visits and can be used by other caregivers.