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Taylor and Francis Group, Synthetic Communications, 13(30), p. 2259-2268, 2000

DOI: 10.1080/00397910008086864

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An alternative stereoselective synthesis of protected trans-5-alkyl-4-hydroxy-2-pyrrolidinones

Journal article published in 2007 by Pq Q. Huang ORCID, 黄培强, 陈安奇, Xu Tang, Aq Q. Chen
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A flexible approach to protected trans-5-alkyl-4-hydroxy-2-pyrrolidinones was described. The key step involved the alpha-amidoalkylation of benzenesulfone derived from (S)-malic acid, with organozinc reagents generated in situ from Grignard reagents and anhydrous ZnCl2. OEt2.