Published in
Elsevier, Tetrahedron Letters, 23(53), p. 2876-2880
DOI: 10.1016/j.tetlet.2012.03.122
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Novel diversely substituted 1-heteroaryl-2-imidazolines for fragment-based drug discovery
Journal article published in 2012 by
Mikhail Krasavin 
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Abstract
A palladium-catalyzed Buchwald–Hartwig arylation protocol has been applied to achieve high-yielding N-heteroarylation of a diverse set of privileged 2-imidazolines. The resulting compounds are of interest as a novel type of molecular tool for fragment-based drug discovery. The potential for combining two 2-imidazoline moieties in a heteroarene-linked dimer via sequential Pd-catalyzed arylation has been demonstrated