Evidence exists for a relationship between glycaemic control and macrovascular disease. Non-enzymatic glycation of proteins may explain this relationship in part. We investigated the effect of blood glucose control, under out-patient conditions, on fibrinogen glycation as well as the relationship between glycated fibrinogen and glycaemic control using a new sensitive method for the measurement of glycated fibrinogen. ; The authors would like to thank the volunteers who took part in the study for their willingness and effort. We would also like to thank Sr. Dorothy Kekana for her hard work in recruiting subjects and in the execution of the intervention. Many thanks also to Dr. Rustem Litvinov and Dr. Robert Ariëns, for their expertise and input in analytic experiments and results. The study was funded by research funds from the North-West University and the University of Pretoria. Insulin was provided by Sanofi-Aventis, South Africa and Novo-Nordisk, South Africa and glucometers by Roche Diagnostics.