Public Library of Science, PLoS ONE, 7(6), p. e22003, 2011
DOI: 10.1371/journal.pone.0022003
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The unparalleled success of combination antiretroviral therapy (cART) is based on the combination of three drugs from two classes. There is insufficient evidence whether simplification to ritonavir boosted protease inhibitor (PI/r) monotherapy in virologically suppressed HIV-infected patients is effective and safe to reduce cART side effects and costs.