Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Reviews Drug Discovery, 11(7), p. 900-907, 2008

DOI: 10.1038/nrd2684

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Genomic-scale prioritization of drug targets: the TDR Targets database

Journal article published in 2008 by Fernán Agüero ORCID, Bissan Al-Lazikani, Martin Aslett, Matthew Berriman, Frederick S. Buckner ORCID, Robert K. Campbell, Santiago Carmona ORCID, Ian M. Carruthers, Buckner Fs, A. W. Edith Chan, Feng Chen, Gregory J. Crowther, Maria A. Doyle, Campbell Rk, Christiane Hertz-Fowler and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Research Support, Non-U.S. Gov't ; Journal Article ; Research Support, N.I.H., Extramural ; The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.