Published in
Elsevier, Materials Chemistry and Physics: Including Materials Science Communications, 3(148), p. 978-987, 2014
DOI: 10.1016/j.matchemphys.2014.09.008
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Magnetoliposomes based on nickel/silica core/shell nanoparticles : synthesis and characterization
,
Isabel Alexandra Domingues Tarroso Gomes,
I. T. Gomes ,
Bernardo G. Almeida,
Jo??o P. Ara??jo,
J. P. Araújo,
Elisabete M. S. Castanheira ,
Paulo J. G. Coutinho
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Abstract
"Available online 18 September 2014" ; In the present work, nickel magnetic nanoparticles with diameters lower than 100nm, with and without silica shell, were synthesized by microheterogeneous templating. The magnetic properties of the nanoparticles show a typical ferromagnetic behavior with a coercive field of 80Oe. Dry magnetoliposomes (DMLs) with diameter between 58nm and 76nm were obtained from the synthesis of nanoparticles in the presence of a lipid or surfactant layer, and aqueous magnetoliposomes (AMLs) were obtained by encapsulation of the nanoparticles in liposomes. FRET (F??rster resonance energy transfer) experiments were performed to study the non-specific interactions between aqueous magnetoliposomes and giant unilamellar vesicles (GUVs), as models of cell membranes. It was possible to detect membrane fusion between GUVs and AMLs containing both NBD-C6-HPC (donor) and the dye Nile Red (acceptor).