Published in

Springer, European Journal of Pediatrics, 11(167), p. 1305-1312, 2008

DOI: 10.1007/s00431-008-0713-2

Links

Tools

Export citation

Search in Google Scholar

Cord blood Clara cell protein CC16 predicts the development of bronchopulmonary dysplasia

Journal article published in 2008 by Alexandra J. J. Schrama, Alfred Bernard, Ben J. H. M. Poorthuis, Aeilko H. Zwinderman, Howard M. Berger, Frans J. Walther ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Clara cell protein (CC16) is an anti-inflammatory protein and a biomarker of pulmonary epithelial cells and alveolocapillary membrane injury in adults. We investigated whether low cord blood concentrations of CC16 are associated with the development of respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in preterm infants and the relationship between CC16 and its pro-inflammatory counterpart, the secretory phospholipase A(2) (sPLA(2)) enzyme. CC16 concentration, sPLA(2) activity and IL-6 concentration were measured in cord blood plasma from 79 preterm infants (25 controls, 37 infants who developed RDS and 17 infants who developed BPD). After adjustment for gestational age and Apgar score at 5 min, the CC16 concentration was lower in BPD infants than in preterm controls (p