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Wiley, Angewandte Chemie, 7(122), p. 1253-1255, 2010

DOI: 10.1002/ange.200902309

Wiley, Angewandte Chemie International Edition, 7(49), p. 1231-1233, 2010

DOI: 10.1002/anie.200902309

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Selective aggregation of a platinum-gadolinium complex within a tumor-cell nucleus

Journal article published in 2010 by Ellen L. Crossley, Jade B. Aitken, Stefan Vogt ORCID, Hugh H. Harris ORCID, Louis M. Rendina
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Hitching a ride: Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex results in the selective aggregation of the intact drug within the cell nuclei, as determined by synchrotron X-ray fluorescence (XRF) imaging (see images). This work is the first example of gadolinium delivery by a platinum complex to a tumor-cell nucleus. ; Ellen L. Crossley, Jade B. Aitken, Stefan Vogt, Hugh H. Harris and Louis M. Rendina