Published in
Lippincott, Williams & Wilkins, Journal of Hypertension, 6(29), p. 1121-1127, 2011
DOI: 10.1097/hjh.0b013e328346d72c
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Association between ADRA1A gene and the metabolic syndrome: candidate genes and functional counterpart in the PAMELA population
Journal article published in 2011 by
Guido Grassi,
Sandosh Padmanabhan,
Cristina Menni,
Gino Seravalle 
,
Wk Lee,
Michele Bombelli,
Gianmaria Brambilla,
Fal Quarti-Trevano,
Cristina Giannattasio,
Giancarlo Cesana,
Anna Dominiczak,
Giuseppe Mancia
,
Wk Lee,
Michele Bombelli,
Gianmaria Brambilla,
Fal Quarti-Trevano,
Cristina Giannattasio,
Giancarlo Cesana,
Anna Dominiczak,
Giuseppe Mancia
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Abstract
There is currently uncertainty about whether metabolic syndrome has a common underlying process. We performed a gene-centric association study of metabolic syndrome in 98 major cardiometabolic genes in the large, well phenotyped Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study. We followed this with functional studies to elucidate a possible mechanism for the top association signal.