As a long-term condition, psoriasis demands significant personal and professional input for optimal self-management. Low levels of well-being and high levels of psychological distress are associated with psoriasis and reduced resources for self-care. Patient-reported outcome (PRO) measures can assess physical, social, and psychological functioning in order to guide treatment decision-making. Many psoriasis PRO measures exist; we systematically reviewed their development and validation to determine appropriateness for use in clinical management. PubMed (Medline), PsycInfo, and Cinhal from inception were systematically searched using predefined search terms and limited to English language and human subjects. Articles were selected for full review through explicit inclusion/exclusion criteria. PRO measures were critically reviewed in accordance with published guidelines and theory on the development and validation of PROs. The search identified 967 abstracts; 71 met criteria for full review. 45 PRO measures were found, 16 specific to psoriasis, 21 assessed other dermatological conditions, and 8 were developed for generic non-dermatological health conditions. The review revealed limitations of existing measures including: a) composite structure assessing multiple, poorly defined concepts; b) lack of evidence for face and content validity; d) failure to include both patient and clinician perspectives andrequirements; and d) lack of evidence of the feasibility and acceptability for patients and physicians. No single PRO measure with adequate evidence of validity, reliability, and sensitivity to change captures patient wellbeing in psoriasis. A valid, sensitive, specific, and acceptable PRO to assess the full impact of psoriasis on wellbeing is needed for the comprehensive clinical management of psoriasis.