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Oxford University Press (OUP), Bioinformatics, 3(27), p. 317-325

DOI: 10.1093/bioinformatics/btq651

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maxAlike: maximum likelihood-based sequence reconstruction with application to improved primer design for unknown sequences

Journal article published in 2010 by Peter Menzel ORCID, Peter F. Stadler ORCID, Jan Gorodkin
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: The task of reconstructing a genomic sequence from a particular species is gaining more and more importance in the light of the rapid development of high-throughput sequencing technologies and their limitations. Applications include not only compensation for missing data in unsequenced genomic regions and the design of oligonucleotide primers for target genes in species with lacking sequence information but also the preparation of customized queries for homology searches.