The lateral continuity of the E–W trending thrust sheets developed within the Lower to Middle Triassic cover of the central Southern Alps (Orobic belt) is disturbed by the occurrence of several N–S trending transverse zones, such as the poorly known Grem–Vedra Transverse Zone (GVTZ). The GVTZ developed during the emplacement of the up to six S-verging thrust sheets consisting of Lower to Middle Triassic units, occurring immediately south of the Orobic Anticlines. The transverse zone, active during thrust emplacement related to the early Alpine compressions which pre-date the Adamello intrusion, includes three major vertical shear zones, the Grem, Pezzel and Zuccone faults. The major structure of the transverse zone is the dextral Grem fault, forming a deep lateral ramp between thrust sheets 3 and 5. A similar evolution also occurred along the Zuccone and Pezzel faults, which show a left-lateral displacement of syn-thrust folds. The Grem fault was later reactivated as an oblique tear fault during the emplacement of the Orobic Anticlines, due to back-thrusting along out-of-sequence thrust surfaces (Clusone fault). Transpressional deformations along the fault zone are recorded by the rotation of major syn-thrust folds, which also suggest a horizontal offset close to 0.5 km. Records of the first stage of evolution of the Grem fault are better preserved along its northern segment, and structural relationships suggest that it propagated southward and downward in the growing thrust stack. The study of the meso and megascopic structures developed along the GVTZ constrains the evolution of the transverse zone, illustrating the complex deformational phenomena occurring in a transpressional regime. The GVTZ probably reflects the existence of pre-existing tectonic lineaments with a similar orientation. Evidence of pre-existing structures are not reserved in the exposed units, nevertheless the N–S extensional fault systems that characterize the Norian to Jurassic rifting history of the Lombardian basin are valid candidates.