Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells

Indzhykulian, Artur A.; Stepanyan, Ruben; Nelina, Anastasiia; Spinelli, Kateri J.; Ahmed, Zubair M.; Belyantseva, Inna A.; Friedman, Thomas B.; Barr-Gillespie, Peter G.; Frolenkov, Gregory I.

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Public Library of Science, PLoS Biology, 6(11), p. e1001583, 2013

DOI: 10.1371/journal.pbio.1001583

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Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells

Journal article published in 2013 by Artur A. Indzhykulian, Ruben Stepanyan, Anastasiia Nelina, Kateri J. Spinelli, Zubair M. Ahmed, Inna A. Belyantseva, Thomas B. Friedman, Peter G. Barr-Gillespie

, Gregory I. Frolenkov

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Abstract

Backscatter scanning electron microscopy and conventional whole cell patch-clamp experiments reveal a two-step mechanism for the regeneration of tip links, the crucial element of mechanotransduction machinery in the hair cells of the inner ear.