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Wiley, Angewandte Chemie International Edition, 50(51), p. 12486-12489, 2012

DOI: 10.1002/anie.201206416

Wiley, Angewandte Chemie, 50(124), p. 12654-12657, 2012

DOI: 10.1002/ange.201206416

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Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres

Journal article published in 2012 by Amirali Popat, Benjamin P. Ross ORCID, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, Shi Zhang Qiao
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released. ; Amirali Popat, Benjamin P. Ross, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, and Shi Zhang Qiao