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Wiley, Arthritis and Rheumatism, 11(62), p. 3289-3299, 2010

DOI: 10.1002/art.27656

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Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis.

Journal article published in 2010 by Joana R. F. Abreu, Sarah Krausz, Wendy Dontje, Aleksander M. Grabiec ORCID, Daphne de Launay, Martijn A. Nolte ORCID, Paul P. Tak, Kris A. Reedquist
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Defective activation of T cell receptor-proximal signaling proteins, such as the small GTPase Rap1, is thought to contribute to the pathologic behavior of rheumatoid arthritis (RA) synovial T cells. This study was undertaken to determine whether maintaining Rap1 signaling in murine T cells modifies disease onset or severity in collagen-induced arthritis (CIA).