Published in

Rockefeller University Press, Journal of Cell Biology, 5(198), p. 773-783, 2012

DOI: 10.1083/jcb.201203170

Links

Tools

Export citation

Search in Google Scholar

Neutrophil extracellular traps: Is immunity the second function of chromatin?

Journal article published in 2012 by Volker Brinkmann, Arturo Zychlinsky
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular and selected cytoplasmic proteins. NETs are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections. This release of chromatin is the result of a unique form of cell death, dubbed “NETosis.” Here we review our understanding of how NETs are made, their function in infections and as danger signals, and their emerging importance in autoimmunity and coagulation.