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American Society for Microbiology, Journal of Virology, 7(81), p. 3181-3186, 2007

DOI: 10.1128/jvi.02386-06

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The Mimivirus Genome Encodes a Mitochondrial Carrier That Transports dATP and dTTP

Journal article published in 2007 by Magnus Monné, Alan J. Robinson, Christoph Boes, Michael E. Harbour, Ian M. Fearnley, Edmund R. S. Kunji ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Members of the mitochondrial carrier family have been reported in eukaryotes only, where they transport metabolites and cofactors across the mitochondrial inner membrane to link the metabolic pathways of the cytosol and the matrix. The genome of the giant virus Mimiviridae mimivirus encodes a member of the mitochondrial carrier family of transport proteins. This viral protein has been expressed in Lactococcus lactis and is shown to transport dATP and dTTP. As the 1.2-Mb double-stranded DNA mimivirus genome is rich in A and T residues, we speculate that the virus is using this protein to target the host mitochondria as a source of deoxynucleotides for its replication.