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Towards boron neutron capture therapy: The formulation and preliminary in vitro evaluation of liposomal vehicles for the therapeutic delivery of the dequalinium salt of bis-nido-carborane

Journal article published in 2013 by Dimitrios Theodoropoulos, Aikaterini Rova, James R. Smith, Eugen Barbu, Gianpiero Calabrese, Ioannis S. Vizirianakis ORCID, John Tsibouklis, Dimitrios G. Fatouros
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Liposomes of phosphatidylcholine or of dimyristoylphosphatidylcholine that incorporate bis-nido-carborane dequalinium salt are stable in physiologically relevant media and have in vitro toxicity profiles that appear to be compatible with potential therapeutic applications. These features render the structures suitable candidate boron-delivery vehicles for evaluation in the Boron Neutron Capture Therapy of cancer.