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Study of some volatile compounds evolved from the thermal decomposition of atenolol

Journal article published in 2013 by A. C. M. Silva, D. A. Galico, D. A. Gálico, R. B. Guerra, A. O. Legendre, Alexandre de Oliveira Legendre, Daniel Rinaldo ORCID, Mario Sergio Galhiane, Gilbert Bannach
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Processo FAPESP: 12/21450-1 ; Simultaneous thermogravimetry-differential scanning calorimetry (TG-DSC) and coupled thermogravimetry-infrared spectroscopy (TG-FTIR) analyses were used to study the antihypertensive drug atenolol. The TG-DSC curves provided information concerning the thermal stability and decomposition profiles of the compound. From the TG-FTIR coupled techniques, it was possible to identify ammonia and isopropylamine as possible volatile compounds released during the thermal decomposition of the drug.