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Thieme Gruppe, Experimental and Clinical Endocrinology and Diabetes, 09(113), p. 522-528, 2005

DOI: 10.1055/s-2005-865807

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Low sex hormone binding globulin is a potential marker for the metabolic syndrome in different ethnic groups

Journal article published in 2005 by A. H. Heald, F. Ivison, S. G. Anderson ORCID, L. Riste, I. Laing, J. K. Cruickshank, J. M. Gibson, Anderson S. F. Ivison Riste L. I. Laing Cruickshank (K Gibson J.-M. Heald A.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Department of Endocrinology, University of Manchester, Salford NHS Trust, Salford, UK. aheald@fs1.ho.man.ac.ukHepatic sex-hormone binding globulin (SHBG) production is down-regulated by insulin and low levels reflect insulin resistance. Because insulin resistance is closely related to the development of cardiovascular disease in different ethnic groups we examined ethnic variation in SHBG across populations with different baseline cardiovascular risk and metabolic syndrome prevalence. Participants were population-based, of European (n = 142), Pakistani (n = 130), and African-Caribbean (AfC) origin (n = 193). SHBG, fasting lipids, and glucose concentrations plus insulin sensitivity (HOMA-S) were determined. Age adjusted SHBG was significantly lower in both Pakistani men and women. Circulating SHBG levels were lower in those with impaired vs. normal glucose homeostasis. SHBG correlated positively with HOMA-S (rho = 0.28, p