Published in

Elsevier, Steroids, 3(73), p. 233-244, 2008

DOI: 10.1016/j.steroids.2007.10.013

Links

Tools

Export citation

Search in Google Scholar

The Role of Estrogens and Estrogen Receptors in Normal Prostate Growth and Disease

Journal article published in 2007 by Gail S. Prins, Kenneth S. Korach ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Estrogens have significant direct and indirect effects on prostate gland development and homeostasis and have been long suspected in playing a role in the etiology of prostatic diseases. Direct effects are mediated through prostatic estrogen receptors alpha (ERalpha) and beta (ERbeta) with expression levels changing over time and with disease progression. The present review examines the evidence for a role of estrogens and specific estrogen receptors in prostate growth, differentiation and disease states including prostatitis, benign prostatic hyperplasia (BPH) and cancer and discusses potential therapeutic strategies for growth regulation via these pathways.