In order to improve quantification of the spatial distribution of carbon sinks and sources in the conterminous USA, we conduct a~nested global atmospheric inversion with consideration of the spatial information of crop production and consumption. Spatially distributed county-level cropland net primary productivity, harvested biomass, soil carbon change, and human and livestock consumption data over the conterminous USA are used for this purpose. Time-dependent Bayesian synthesis inversions are conducted based on CO 2 observations at 210 stations to infer CO 2 fluxes globally at monthly time steps with a nested focus on 30 regions in North America. Prior land surface carbon fluxes are first generated using a biospheric model, and the inversions are constrained using prior fluxes with and without adjustments for crop production and consumption over the 2002–2007 period. After these adjustments, the inverted regional carbon sink in the US Midwest increases from 0.25 ± 0.03 Pg C yr −1 to 0.42 ± 0.13 Pg C yr −1 , whereas the large sink in the US Southeast forest region is weakened from 0.41 ± 0.12 Pg C yr −1 to 0.29 ± 0.12 Pg C yr −1 . These adjustments also reduce the inverted sink in the West region from 0.066 ± 0.04 Pg C yr −1 to 0.040 ± 0.02 Pg C yr −1 because of high crop consumption and respiration by humans and livestock. The general pattern of sink increase in crop production areas and sink decreases (or source increases) in crop consumption areas highlights the importance of considering the lateral carbon transfer in crop products in atmospheric inverse modeling, which provides an atmospheric perspective of the overall carbon balance of a region.