In preparation for the upcoming sample return missions containing potential biohazards which may have withstood the rigors of space travel we present a hyperspectral method of in-situ analysis of grains combining several non-destructive imaging diagnostics, performed in BSL4 quarantine conditions. This offers an alternative to the analyses in facilities at large, using optimized experimental setups while keeping the samples in conditions of quarantine. Our methodology was tested during analyses of meteorites and cometary and interstellar grains from the recent NASA Stardust mission.