We present a synchrotron X-ray diffraction study of pressure-induced changes in nanocrystalline anatase (with a crystallite size of 30–40 nm) to 35 GPa. The nanoanatase was observed to a pressure above 20 GPa. Direct transformation to the baddeleyite-TiO2 polymorph was seen at 18 GPa. A fit of the pressure versus volume data to a Birch–Murnaghan equation yielded the following parameters: zero-pressure volume, V0=136.15 Å3, bulk modulus, KT=243(3) GPa, and the pressure derivative of bulk modulus, K′=4 (fixed). The bulk modulus value obtained for the nanocrystalline anatase is about 35% larger than that of the macrocrystalline counterpart.