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Elsevier, American Journal of Medicine, 2(119), p. 167.e9-167.e15, 2006

DOI: 10.1016/j.amjmed.2005.08.001

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Low insulin-like growth factor-II levels predict weight gain in normal weight subjects with type 2 diabetes.

Journal article published in 2006 by Adrian H. Heald, Lars Kärvestedt, Simon G. Anderson ORCID, Julie McLaughlin, Anne Knowles, Louise Wong, Valdemar Grill, J. Kennedy Cruickshank, Anne White, J. Martin Gibson, Kerstin Brismar, A. Karvestedt L. Anderson SG McLaughlin J. Knowles A. Wong L. Grill V. Cruickshank (K White A. Gibson JM Brismar K. Heald
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Abstract

PURPOSE: Insulin-like growth factor (IGF)-I and IGF-II are important in the regulation of metabolism and growth. We previously reported in normoglycemic individuals of normal weight that low circulating IGF-II predicts future weight gain. We subsequently investigated whether such relationships persisted in circumstances of type 2 diabetes. METHODS: In 224 subjects with type 2 diabetes we assessed the association between baseline IGF-II levels and risk of weight gain (>2.0 kg) at the 5-year follow-up. RESULTS: At follow-up, 90 participants (40.2%) gained more than 2.0 kg in body weight. For subjects (body mass index