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Wiley, Diabetic Medicine, 2(24), p. 145-153, 2007

DOI: 10.1111/j.1464-5491.2007.02032.x

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Change in pancreatic B-cell function (HOMA-B) varies in different populations with similar genetic backgrounds but different environments.

Journal article published in 2007 by A. H. Heald, S. G. Anderson ORCID, J. Patel, A. Rudenski, A. Vyas, A. Yates, E. Hughes, D. Prabharakan, S. Reddy, P. Durrington, J. M. Gibson, D. Bhatnagar, J. K. Cruickshank, I. Laing
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

OBJECTIVE: To determine whether pancreatic B-cell function varies in different populations with similar genetic backgrounds but different environments. RESEARCH DESIGN/METHODS: We compared a specific migrant Gujarati community in the UK (n = 205) with people still resident in the same villages of origin in Gujarat, India (n = 246). Pancreatic B-cell function (HOMA-B) was determined and the influence of age, migration and other factors was explored. RESULTS: As anticipated, there was an age-related decline in log(HOMA-B) in both groups. However, the age-related fall in log(HOMA-B) was more pronounced in the UK than in Gujarat (normalized beta-0.29 vs. -0.14, P for difference = 0.03). The decline of HOMA-B with age persisted after adjustment for body mass index (UK beta = -0.31; Gujarat beta = -0.16, P = 0.015, P