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Elsevier, Bioorganic and Medicinal Chemistry Letters, 2(13), p. 265-267, 2003

DOI: 10.1016/s0960-894x(02)00923-x

Wiley-VCH Verlag, ChemInform, 19(34), 2003

DOI: 10.1002/chin.200319180

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The preparation of (S)-aspartate semi-aldehyde appropriate for use in biochemical studies

Journal article published in 2003 by Sarah J. Roberts, Jonathan C. Morris ORCID, Renwick C. J. Dobson, Juliet A. Gerrard
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Abstract

We report two three-step syntheses of (S)-aspartate semi-aldehyde, an important synthetic and biosynthetic precursor, from diprotected aspartic acid. The first synthesis proceeds via a thioester, the second via a Weinreb amide. Each route yields pure (S)-aspartate semi-aldehyde in excellent yield. (S)-Aspartate semi-aldehyde prepared in this manner has proved appropriate as a substrate for detailed enzyme studies. ; http://www.elsevier.com/wps/find/journaldescription.cws_home/972/description#description ; Sarah J. Roberts, Jonathan C. Morris, Renwick C. J. Dobson and Juliet A. Gerrard ; Copyright © 2002 Elsevier Science Ltd. All rights reserved.