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American Medical Association, Archives of General Psychiatry, 7(66), p. 773

DOI: 10.1001/archgenpsychiatry.2009.83

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Genome-wide association study of alcohol dependence

Journal article published in 2009 by Jens Treutlein, Sven Cichon, Monika Ridinger, Norbert Wodarz, Michael Soyka, Peter Zill, Wolfgang Maier, Rainald Moessner, Wolfgang Gaebel, Norbert Dahmen, Christoph Fehr, Norbert Scherbaum, Michael Steffens, Kerstin U. Ludwig, Josef Frank and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Context: Alcohol dependence is a serious and common public health problem. It is well established that genetic factors play a major role in the development of this disorder. Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder.Objective: To identify susceptibility genes for alcohol dependence through a genome-wide association study (GWAS) and a follow-up study in a population of German male inpatients with an early age at onset. Design: The GWAS tested 524 396 single-nucleotide polymorphisms (SNPs). All SNPs with P