Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

Tsoi, Lc C.; van de Kerkhof, Peter C.; Zeeuwen, Pljm L. J. M.; Young, Hs S.; den Heijer, Martin; Zawirska, Agnieszka; Spain, Sl L.; Stuart, Pe E.; Knight, Jo; Li, Yanming; Li, J.; Ellinghaus, Eva; Gudjonsson, Je E.; Kang, Hm M.; Allen, Mh H.; Capon, Francesca; David Burden, A.; Ding, Jun; Smith, Ch H.; Tejasvi, Trilokraj; Cork, Mj J.; Bowcock, Am M.; Stahle, Mona; Nestle, Fo O.; McManus, Ross; Naluai, Åt; Novelli, Giuseppe; Samuelsson, Lena; Pearson, Rd D.; Schalkwijk, Joost; Erich Wichmann, H.; Spencer, Cc C. A.; Ståhle, Mona; Burden, Ad David; Li, Yun; Lim, Hw W.; Estivill, Xavier; Nnair, Rp P.; Rosen, Cf F.; Krueger, Gerald Gg; Ttrembath, R.; Weger, Wolfgang; Griffiths, Ce E. M.; Eelder, Jt T.; Worthington, Jane; Tazi-Ahnini, Rachid; Duffin, Kc C.; Hayday, Adrian; Helms, Cindy; Hoffmann, Per; Malloy, Mj J.; Goldgar, David; Winkelmann, Juliane; Paschall, Justin; Wijmenga, Cisca; Pullinger, Cr R.; Langford, Cordelia; Gardner, Jennifer; Kane, Jp P.; Edkins, Sarah; Perlmutter, Amy; Miner, Andrew; Feng, Bj J.; Andrews, Robert; Hiremagalore, Ravi; Ike, Robert W.; Christophers, Enno; Blackburn, Hannah; Henseler, Tilo; Schrodi, Sj J.; Strange, Amy; Ruether, Andreas; Prahalad, Sampath; Band, Gavin; Fischer, Judith; Guthery, Sl L.; Liao, Wilson; Vukcevic, Damjan; Kwok, Pui; Menter, Alan; Lathrop, Gm Mark; Weale, Me E.; Deloukas, Panos; Wise, C.; Begovich, Ann B.; Mrowietz, Ulrich; Onoufriadis, Alexandros; Barker, Jn N.; Schreiber, Stefan; Hofer, Angelika; Salmhofer, Wolfgang; Wolf, Peter; Weidinger, Stephan; Mark Lathrop, G.; Kainu, Kati; Koks, Sulev; Saarialho-Kere, Ulpu; Suomela, Sari; Badorf, Petra; Hüffmeier, Ulrike; Küster, Wolfgang; Esko, Tonu; Kingo, Külli; Hueffmeier, Ulrike; Kurrat, Werner; Mössner, Rotraut; Metspalu, Andres; Lascorz, Jesús; Kuester, Wolfgang; Schürmeier-Horst, Funda; Van De Kerkhof, Pc C.; Moessner, Rotraut; Voorhees, John Jj; Ständer, Markward; Weichenthal, Michael; Staender, Markward; Bergboer, Jgm G. M.; Traupe, Heiko; Wichmann, He Erich; Heijer, Martin den; Chandran, Vinod; Barnes, Louise; Campbell, Le E.; Cusack, Caitriona; Duffin, Kristina Callis; Rahman, Proton; Coleman, Ciara; Conroy, Judith; Ennis, Sean; Fitzgerald, Oliver; Gladman, Dafna D.; Gallagher, Phil; Irvine, Ad D.; Kirby, Brian; Markham, Trevor; McLean, Whi H. Irwin; Reis, Andre; McPartlin, Joe; Ryan, Aw W.; Kere, Juha; Rogers, Sf F.; Irwin McLean, W. H.; Giardina, Emiliano; Lepre, Tiziana; Perricone, Carlo; Pujol, Rm M.; Martín-Ezquerra, Gemma; Riveira-Munoz, Eva; Naluai, Å. T.; Naluai, Asa T.; Inerot, Annica; Mallbris, Lotus; Franke, Andre; Wolk, Katarina; Warren, Rb B.; Leman, Joyce; Barton, Anne; Ike, Rw W.; Ricano-Ponce, Isis; Abecasis, Goncalo R.; Pellett, Fj J.; Trynka, Gosia; Henschel, Andrew; Aurand, Marin; Bebo, Bruce; Gieger, Christian; Illig, Thomas; Jöckel, Karl-Heinz; Moebus, Susanne; Erbel, Raimund; Joeckel, Karl-Heinz; Donnelly, Peter; Blackwell, Jm M.; Erbe, Raimund; Peltonen, Leena; Bramon, Elvira; Casas, Jp P.; Brown, Matthew A.; Corvin, Aiden; Mathew, Cg G.; Craddock, Nicholas; Duncanson, Audrey; Markus, Hs S.; Jankowski, Janusz; McCarthy, Mi I.; Palmer, Cna N. A.; Viswanathan, Ac C.; Plomin, Robert; Wood, Nw W.; Rautanen, Anna; Sawcer, Sj J.; Samani, Nilesh; Bellenguez, Céline; Freeman, Colin; Hunt, Se E.; Hellenthal, Garrett; Giannoulatou, Eleni; Bumpstead, Sj J.; Pirinen, Matti; Su, Zhan; Gwilliam, Rhian; McCann, Ot T.; Dronov, Serge; Gillman, Matthew; Nair, Rp P.; Gray, Emma; Hammond, Naomi; Perez, Ml L.; (Casp), Collaborative Association Study of Psoriasis; Jayakumar, Alagurevathi; Abecasis, Gr R.; Potter, Sc C.; Liddle, Jennifer; Consortium, Genetic Analysis of Psoriasis; Ravindrarajah, Radhi; Ricketts, Michelle; Barker, Jnwn N. W. N.; Waller, Matthew; Neir, Rp P.; Weston, Paul; 2., Wellcome Trust Case Control Consortium; Widaa, Sara; Whittaker, Pamela; Extension, Psoriasis Association Genetics; Psoriasi, Collaborative Assoc Study; Elder, Jt T.; Consortium, Genetic Anal Psoriasis; Hiregalore, R.; Trembath, Rc C.; Consor, Wellcome Trust Case Control; Tsoi Lc, Spain SL Knight J Ellinghaus E Stuart PE Capon F Ding J Li Y Tejasvi T Gudjonsson JE Kang HM Allen MH McManus R Novelli G Samuelsson L Schalkwijk J Ståhle M Burden AD Smith CH Cork MJ Estivill X Bowcock AM Krueger GG Weger W Worthington J Tazi-Ahnini R Nes

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Lam Cheung Tsoi
Tsoi et al., 2012

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@article{Tsoi2012,
  abstract = {To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense. © 2012 Nature America, Inc. All rights reserved.},
  author = {Tsoi, Lc C. and van de Kerkhof, Peter C. and Zeeuwen, Pljm L. J. M. and Young, Hs S. and den Heijer, Martin and Zawirska, Agnieszka and Spain, Sl L. and Stuart, Pe E. and Knight, Jo and Li, Yanming and Li, J. and Ellinghaus, Eva and Gudjonsson, Je E. and Kang, Hm M. and Allen, Mh H. and Capon, Francesca and David Burden, A. and Ding, Jun and Smith, Ch H. and Tejasvi, Trilokraj and Cork, Mj J. and Bowcock, Am M. and Stahle, Mona and Nestle, Fo O. and McManus, Ross and Naluai, Åt and Novelli, Giuseppe and Samuelsson, Lena and Pearson, Rd D. and Schalkwijk, Joost and Erich Wichmann, H. and Spencer, Cc C. A. and Ståhle, Mona and Burden, Ad David and Li, Yun and Lim, Hw W. and Estivill, Xavier and Nnair, Rp P. and Rosen, Cf F. and Krueger, Gerald Gg and Ttrembath, R. and Weger, Wolfgang and Griffiths, Ce E. M. and Eelder, Jt T. and Worthington, Jane and Tazi-Ahnini, Rachid and Duffin, Kc C. and Hayday, Adrian and Helms, Cindy and Hoffmann, Per and Malloy, Mj J. and Goldgar, David and Winkelmann, Juliane and Paschall, Justin and Wijmenga, Cisca and Pullinger, Cr R. and Langford, Cordelia and Gardner, Jennifer and Kane, Jp P. and Edkins, Sarah and Perlmutter, Amy and Miner, Andrew and Feng, Bj J. and Andrews, Robert and Hiremagalore, Ravi and Ike, Robert W. and Christophers, Enno and Blackburn, Hannah and Henseler, Tilo and Schrodi, Sj J. and Strange, Amy and Ruether, Andreas and Prahalad, Sampath and Band, Gavin and Fischer, Judith and Guthery, Sl L. and Liao, Wilson and Vukcevic, Damjan and Kwok, Pui and Menter, Alan and Lathrop, Gm Mark and Weale, Me E. and Deloukas, Panos and Wise, C. and Begovich, Ann B. and Mrowietz, Ulrich and Onoufriadis, Alexandros and Barker, Jn N. and Schreiber, Stefan and Hofer, Angelika and Salmhofer, Wolfgang and Wolf, Peter and Weidinger, Stephan and Mark Lathrop, G. and Kainu, Kati and Koks, Sulev and Saarialho-Kere, Ulpu and Suomela, Sari and Badorf, Petra and Hüffmeier, Ulrike and Küster, Wolfgang and Esko, Tonu and Kingo, Külli and Hueffmeier, Ulrike and Kurrat, Werner and Mössner, Rotraut and Metspalu, Andres and Lascorz, Jesús and Kuester, Wolfgang and Schürmeier-Horst, Funda and Van De Kerkhof, Pc C. and Moessner, Rotraut and Voorhees, John Jj and Ständer, Markward and Weichenthal, Michael and Staender, Markward and Bergboer, Jgm G. M. and Traupe, Heiko and Wichmann, He Erich and Heijer, Martin den and Chandran, Vinod and Barnes, Louise and Campbell, Le E. and Cusack, Caitriona and Duffin, Kristina Callis and Rahman, Proton and Coleman, Ciara and Conroy, Judith and Ennis, Sean and Fitzgerald, Oliver and Gladman, Dafna D. and Gallagher, Phil and Irvine, Ad D. and Kirby, Brian and Markham, Trevor and McLean, Whi H. Irwin and Reis, Andre and McPartlin, Joe and Ryan, Aw W. and Kere, Juha and Rogers, Sf F. and Irwin McLean, W. H. and Giardina, Emiliano and Lepre, Tiziana and Perricone, Carlo and Pujol, Rm M. and Martín-Ezquerra, Gemma and Riveira-Munoz, Eva and Naluai, Å. T. and Naluai, Asa T. and Inerot, Annica and Mallbris, Lotus and Franke, Andre and Wolk, Katarina and Warren, Rb B. and Leman, Joyce and Barton, Anne and Ike, Rw W. and Ricano-Ponce, Isis and Abecasis, Goncalo R. and Pellett, Fj J. and Trynka, Gosia and Henschel, Andrew and Aurand, Marin and Bebo, Bruce and Gieger, Christian and Illig, Thomas and Jöckel, Karl-Heinz and Moebus, Susanne and Erbel, Raimund and Joeckel, Karl-Heinz and Donnelly, Peter and Blackwell, Jm M. and Erbe, Raimund and Peltonen, Leena and Bramon, Elvira and Casas, Jp P. and Brown, Matthew A. and Corvin, Aiden and Mathew, Cg G. and Craddock, Nicholas and Duncanson, Audrey and Markus, Hs S. and Jankowski, Janusz and McCarthy, Mi I. and Palmer, Cna N. A. and Viswanathan, Ac C. and Plomin, Robert and Wood, Nw W. and Rautanen, Anna and Sawcer, Sj J. and Samani, Nilesh and Bellenguez, Céline and Freeman, Colin and Hunt, Se E. and Hellenthal, Garrett and Giannoulatou, Eleni and Bumpstead, Sj J. and Pirinen, Matti and Su, Zhan and Gwilliam, Rhian and McCann, Ot T. and Dronov, Serge and Gillman, Matthew and Nair, Rp P. and Gray, Emma and Hammond, Naomi and Perez, Ml L. and (Casp), Collaborative Association Study of Psoriasis and Jayakumar, Alagurevathi and Abecasis, Gr R. and Potter, Sc C. and Liddle, Jennifer and Consortium, Genetic Analysis of Psoriasis and Ravindrarajah, Radhi and Ricketts, Michelle and Barker, Jnwn N. W. N. and Waller, Matthew and Neir, Rp P. and Weston, Paul and 2., Wellcome Trust Case Control Consortium and Widaa, Sara and Whittaker, Pamela and Extension, Psoriasis Association Genetics and Psoriasi, Collaborative Assoc Study and Elder, Jt T. and Consortium, Genetic Anal Psoriasis and Hiregalore, R. and Trembath, Rc C. and Consor, Wellcome Trust Case Control and Tsoi Lc, Spain SL Knight J Ellinghaus E Stuart PE Capon F Ding J Li Y Tejasvi T Gudjonsson JE Kang HM Allen MH McManus R Novelli G Samuelsson L Schalkwijk J Ståhle M Burden AD Smith CH Cork MJ Estivill X Bowcock AM Krueger GG Weger W Worthington J Tazi-Ahnini R Nes},
  doi = {10.1038/ng.2467},
  month = {nov},
  title = {Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.},
  url = {http://www.nature.com/articles/ng.2467.pdf},
  year = {2012}
}

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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

Journal article published in 2012 by Lc C. Tsoi

, Peter C. van de Kerkhof, Pljm L. J. M. Zeeuwen, Hs S. Young

, Martin den Heijer, Agnieszka Zawirska, Sl L. Spain

, Pe E. Stuart, Jo Knight, Yanming Li, J. Li, Eva Ellinghaus

, Je E. Gudjonsson, Hm M. Kang, Mh H. Allen and other authors. Lc C. Tsoi

, Peter C. van de Kerkhof, Pljm L. J. M. Zeeuwen, Hs S. Young

, Martin den Heijer, Agnieszka Zawirska, Sl L. Spain

, Pe E. Stuart, Jo Knight, Yanming Li, J. Li, Eva Ellinghaus

, Je E. Gudjonsson, Hm M. Kang, Mh H. Allen, Francesca Capon

, A. David Burden, Jun Ding, Ch H. Smith, Trilokraj Tejasvi, Mj J. Cork, Am M. Bowcock, Mona Stahle, Fo O. Nestle, Ross McManus, Åt Naluai, Giuseppe Novelli, Lena Samuelsson, Rd D. Pearson, Joost Schalkwijk, H. Erich Wichmann, Cc C. A. Spencer, Mona Ståhle, Ad David Burden, Yun Li, Hw W. Lim, Xavier Estivill, Rp P. Nnair, Cf F. Rosen, Gerald Gg Krueger, R. Ttrembath, Wolfgang Weger, Ce E. M. Griffiths

, Jt T. Eelder, Jane Worthington, Rachid Tazi-Ahnini, Kc C. Duffin, Adrian Hayday, Cindy Helms, Per Hoffmann

, Mj J. Malloy, David Goldgar, Juliane Winkelmann, Justin Paschall, Cisca Wijmenga

, Cr R. Pullinger, Cordelia Langford, Jennifer Gardner, Jp P. Kane, Sarah Edkins, Amy Perlmutter, Andrew Miner, Bj J. Feng, Robert Andrews, Ravi Hiremagalore, Robert W. Ike, Enno Christophers, Hannah Blackburn, Tilo Henseler, Sj J. Schrodi, Amy Strange, Andreas Ruether, Sampath Prahalad, Gavin Band, Judith Fischer, Sl L. Guthery, Wilson Liao, Damjan Vukcevic, Pui Kwok, Alan Menter, Gm Mark Lathrop, Me E. Weale, Panos Deloukas

, C. Wise, Ann B. Begovich, Ulrich Mrowietz, Alexandros Onoufriadis, Jn N. Barker, Stefan Schreiber, Angelika Hofer, Wolfgang Salmhofer, Peter Wolf, Stephan Weidinger

, G. Mark Lathrop, Kati Kainu, Sulev Koks

, Ulpu Saarialho-Kere, Sari Suomela, Petra Badorf, Ulrike Hüffmeier, Wolfgang Küster, Tonu Esko

, Külli Kingo, Ulrike Hueffmeier, Werner Kurrat, Rotraut Mössner, Andres Metspalu, Jesús Lascorz, Wolfgang Kuester, Funda Schürmeier-Horst, Pc C. Van De Kerkhof, Rotraut Moessner, John Jj Voorhees, Markward Ständer, Michael Weichenthal, Markward Staender, Jgm G. M. Bergboer, Heiko Traupe, He Erich Wichmann, Martin den Heijer

, Vinod Chandran, Louise Barnes, Le E. Campbell, Caitriona Cusack, Kristina Callis Duffin, Proton Rahman, Ciara Coleman, Judith Conroy, Sean Ennis, Oliver Fitzgerald, Dafna D. Gladman, Phil Gallagher, Ad D. Irvine

, Brian Kirby, Trevor Markham, Whi H. Irwin McLean, Andre Reis

, Joe McPartlin, Aw W. Ryan, Juha Kere, Sf F. Rogers, W. H. Irwin McLean, Emiliano Giardina, Tiziana Lepre, Carlo Perricone, Rm M. Pujol, Gemma Martín-Ezquerra, Eva Riveira-Munoz, Å. T. Naluai, Asa T. Naluai

, Annica Inerot, Lotus Mallbris, Andre Franke, Katarina Wolk, Rb B. Warren, Joyce Leman, Anne Barton

, Rw W. Ike, Isis Ricano-Ponce, Goncalo R. Abecasis, Fj J. Pellett, Gosia Trynka, Andrew Henschel, Marin Aurand, Bruce Bebo, Christian Gieger

, Thomas Illig, Karl-Heinz Jöckel, Susanne Moebus, Raimund Erbel, Karl-Heinz Joeckel, Peter Donnelly, Jm M. Blackwell, Raimund Erbe, Leena Peltonen, Elvira Bramon, Jp P. Casas, Matthew A. Brown, Aiden Corvin, Cg G. Mathew, Nicholas Craddock, Audrey Duncanson, Hs S. Markus, Janusz Jankowski, Mi I. McCarthy, Cna N. A. Palmer, Ac C. Viswanathan, Robert Plomin

, Nw W. Wood, Anna Rautanen, Sj J. Sawcer, Nilesh Samani, Céline Bellenguez, Colin Freeman, Se E. Hunt, Garrett Hellenthal, Eleni Giannoulatou, Sj J. Bumpstead, Matti Pirinen, Zhan Su, Rhian Gwilliam, Ot T. McCann, Serge Dronov, Matthew Gillman, Rp P. Nair, Emma Gray, Naomi Hammond, Ml L. Perez, Collaborative Association Study of Psoriasis (Casp), Alagurevathi Jayakumar, Gr R. Abecasis, Sc C. Potter, Jennifer Liddle, Genetic Analysis of Psoriasis Consortium, Radhi Ravindrarajah, Michelle Ricketts, Jnwn N. W. N. Barker, Matthew Waller, Rp P. Neir, Paul Weston, Wellcome Trust Case Control Consortium 2., Sara Widaa, Pamela Whittaker, Psoriasis Association Genetics Extension, Collaborative Assoc Study Psoriasi, Jt T. Elder, Genetic Anal Psoriasis Consortium, R. Hiregalore, Rc C. Trembath, Wellcome Trust Case Control Consor, Spain SL Knight J Ellinghaus E Stuart PE Capon F Ding J Li Y Tejasvi T Gudjonsson JE Kang HM Allen MH McManus R Novelli G Samuelsson L Schalkwijk J Ståhle M Burden AD Smith CH Cork MJ Estivill X Bowcock AM Krueger GG Weger W Worthington J Tazi-Ahnini R Nes Tsoi Lc

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Abstract

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense. © 2012 Nature America, Inc. All rights reserved.

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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.

Abstract