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Nature Research, Nature Genetics, 3(41), p. 280-282, 2009

DOI: 10.1038/ng.307

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New susceptibility locus for coronary artery disease on chromosome 3q22.3

Journal article published in 2009 by Wellcome Trust Case Control Consor, Anika Großhennig, Myocardial Infarction Genetics Con, Jeanette Erdmann, Peter S. Braund, Anika Grosshennig, Inke R. König, Braund Ps, Alistair S. Hall, König Ir, Christian Hengstenberg, Hall As, Patrick Linsel-Nitschke, David-Alexandre Tregouet, Sekar Kathiresan and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).