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Hindawi, BioMed Research International, (2014), p. 1-8, 2014

DOI: 10.1155/2014/840921

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Analysis of Differential miRNA Expression in Primary Tumor and Stroma of Colorectal Cancer Patients

Journal article published in 2014 by Giuseppina Della Vittoria Scarpati, Enrica Calura ORCID, Mariacristina Di Marino ORCID, Chiara Romualdi ORCID, Luca Beltrame ORCID, Umberto Malapelle ORCID, Giancarlo Troncone, Alfonso De Stefano ORCID, Stefano Pepe, Sabino De Placido, Maurizio D'Incalci, Sergio Marchini, Chiara Carlomagno
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Microarray technology was used to profile miRNA expression in primary tumor and stromal tissue from paraffin embedded material of 51 patients with colorectal cancer. 26 miRNAs resulted differentially expressed with at least 2-fold change in tumor tissue with respect to stroma (16 more expressed in the tumor and 10 more expressed in the stroma). 10/26 were confirmed as differentially expressed at qRTPCR: miR-200c-3p, miR-141-3p, miR-200b-3p, miR-200a-3p, miR-1246, miR-92a-3p, miR-194-5p, miR-192-5p, miR-3651-5p, and miR-574-3p. No significant association was found between miRNA expressions and stage at diagnosis, site of primary tumor, first site of metastasis, progression-free, or overall survival.