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Mendelian randomization of blood lipids for coronary heart disease.
Journal article published in 2014 by
Michael V. Holmes,
Erik P. A. van Iperen,
E. P. A. Van Iperen,
.. Ucleb consortium,
Jon White,
Delilah Zabaneh,
Yvonne T. van der Schouw 
,
Michael Y. Tsai,
Wm Monique Verschuren,
Y. T. Van Der Schouw,
Paul I. W. de Bakker,
Hugh Watkins,
James G. Wilson,
Folkert W. Asselbergs,
Tom M. Palmer
and other authors.
,
Michael Y. Tsai,
Wm Monique Verschuren,
Y. T. Van Der Schouw,
Paul I. W. de Bakker,
Hugh Watkins,
James G. Wilson,
Folkert W. Asselbergs,
Tom M. Palmer
and other authors.
Abstract
AIMS: To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. METHODS AND RESULTS: We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two scores. The first was unrestricted, including all independent SNPs associated with the lipid trait identified from a prior meta-analysis (threshold P